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CIRC Seminar – Bryn Martin
January 29 @ 4:10 pm - 5:00 pm
The Center for Institutional Research Computing’s January seminar will be given by Dr. Bryn Martin, University of Idaho, Biological Engineering.
The talk will be held in SPARK G10, coffee and light refreshments will be served.
Biomechanical Modeling of Cerebrospinal Fluid Solute Transport: Relevance to Subarachnoid Hemorrhage and Intrathecal Drug Delivery
Abstract: As a fluidic medium in direct contact with the central nervous system (CNS), cerebrospinal fluid (CSF) plays an important role in biomechanical support and physiological function of the brain and the spinal cord and struck popular interest with relevance to the “glymphatic” system. Although the mechanisms driving pulsatile CSF flow are still not fully understood, novel imaging techniques have illuminated the normative range of this flow as well as its variations in the presence of neural disorders. The significance of CSF dynamics in normal and neuropathological conditions has been investigated in multiple in vivo and numerical studies. CSF also provides an alternative route for the delivery of therapeutic agents to the CNS and removal of unwanted substances from the CSF. Intrathecal drug delivery techniques facilitate transport of large biomolecules to the CNS by bypassing the blood-brain barrier. In this presentation, I will focus on our progress and findings in biomechanical modeling of CSF solute transport in two specific applications: subarachnoid hemorrhage and intrathecal drug delivery. Future studies on CSF will shed more light on its importance in the assessment and treatment of neurological conditions.
Biography: Dr. Bryn Martin is an assistant professor of Biological Engineering at University of Idaho (2015-present) and leads research within the Neurophysiological Imaging and Modeling Laboratory (www.NIML.org). Martin conducts clinical translational research that aims to improve human health and well-being for the millions of people affected by central nervous system (CNS) disorders. His research develops and applies advanced MR imaging and computational modeling techniques to investigate the pathophysiology of CNS disorders and therapeutics from a hydrodynamic and biomechanical perspective and develop related medical technologies. Prior to joining U of I, Martin served as director of the Conquer Chiari Research Center at the University of Akron (2012-15), completed post-doctoral training at the Swiss Federal Institute of Technology (2009-12) and earned a doctorate in Mechanical Engineering at the University of Illinois at Chicago (2008). Martin has been employed in a number of medical device companies and is an active medTech inventor, consultant, and scientific advisory board member. He serves as executive board member to a number of international societies in the field of cerebrospinal fluid dynamics and CNS diseases.